Abstract: There were numerous factors affecting the unit capacity of production of the new vertical filter press. In order to improve the unit capacity of production of the vertical filter press, the research on the different thickness of the filter chamber of the new vertical filter press had been carried out. Three-dimensional modeling was conducted through Solidworks and imported into Fluent software for mesh division and boundary conditions setting. Through the comparison of five groups of different filter chamber thicknesses, the volume fraction of solid phase and the time to achieve dynamic equilibrium and stability were observed to find the optimal filter chamber thickness. It was found in the simulation test and comparison of the filter chamber thickness that the capacity of production per unit time of the 15 mm filter chamber reached the maximum, and the solid phase volume fraction reached 89.9%, which provided a reference for guiding the actual work.