Abstract: A copper-lead-zinc polymetallic ore in Qinghai has characteristics of complex ore properties, low copper-lead-zinc content, high sulfur content, and high argillated gangue content, so it is difficult to beneficiate. In order to achieve efficient separation and high recovery of useful minerals in the ores, a separating technique with flotation flowsheet consisting of copper-lead bulk and Seperating flotation-sulfur flotation-zinc flotation was adopted. When the grades of copper, lead, zinc and sulfur in the ore are 0.10%, 0.31%, 0.40% and 21.58%, by the closed-circuit test copper concentrate grading 13.96% copper with recovery of 74.86%, a sulphur concentrate grading 38.25% sulfur with recovery of 90.24%, a low-grade lead concentrate grading 17.85% lead with recovery of 78.84%, and a low-grade zinc concentrate grading 15.45% zinc with recovery of 67.75% were obtained. The separation and recovery of valuable elements in the ore are realized.