Abstract: Objective In order to increase the flotation efficiency of gold mines, mining plants often add flotation reagents to the dereagent system, which results in a large amount of flotation reagents in the flotation gold concentrate, especially collectors and frothers. The adsorption state of collectors on mineral surface is relatively complex, with most of them mainly relying on chemical adsorption and difficult to naturally desorb. The synergistic effect of frothers and collectors makes the existence forms of reagents on mineral surface more complex and difficult to remove. Flotation gold concentrates often contain a large amount of flotation reagents. These reagents can have adverse effects on subsequent microbial preoxidation operations, fine grinding cyanidation operations and carbon adsorption operations. Therefore, it is necessary to undergo dereagent treatment of gold concentrate before microbial preoxidation or cyanidation. Method According to the principle of dereagent process, the dereagent process can be divided into the physical dereagent process, the chemical dereagent process, and the physical-chemical combined dereagent process. The physical dereagent process is green and has high universality, but it is inefficient and generates a lot of wastewater. The chemical dereagent process is complete and efficient, but it is pollution, high cost, and requires subsequent wastewater treatment. The physical-chemical combined dereagent process can achieve low-pollution and efficient dereagent by combining the advantages of two dereagent processes, while it will increase the process flow and equipment cost. Result&Conclusion Green and efficient dereagent processes are an important research direction, and improving the cyclic treatment and utilization of dereagent wastewater, while achieving short process and automation of dereagent equipment, are also a trend in the development of dereagent processes.