Abstract: Objective The flotation purification of phosphogypsum is an important way for its resource utilization. To solve the problems of traditional flotation collectors such as sensitivity to slime, poor solubility, difficulty in degradation and instability, Method based on the phosphogypsum of a mining company in Yichang, Hubei Province, a self-made quaternary ammonium salt collector (LLSG-1) was developed. The experiments of reverse flotation purification, impurity removal and whitening of phosphogypsum were carried out. Result Using the raw ore with a purity of 88.14%, a whiteness of 33.88%, and a SiO₂ content of 6.26%, at the condition of pH value ranging from 2.3 to 2.5, with LSG-1 as the collector and MIBC as the foaming agent, after three-stage flotation, a purity of 93.61% and a whiteness of 65.19% were obtained. Phosphogypsum concentrate with a SiO₂ content of 1.87% was also obtained. Conclusion The quality of the concentrate meets the first-class standard for building gypsum as stipulated in GB/T 23456-2018 "Phosphogypsum". The research provides technical support for the efficient recovery of phosphogypsum resources.