Abstract: This is an article in the field of mineral processing engineering. Lithium ore is an important strategic resource in China. At present, flotation is the most commonly used method for the separation of lithium ore. In this article, the crystal structure characteristics of spodumene and its interaction mechanism with flotation agent are discussed from the point of view of spodumene crystal structure. This article describes it from seven aspects: metal cationic activator, organic inhibitor, inorganic inhibitor, anionic collector, cationic collector, mixed collector and new collector. It is of great significance to understand the characteristics of the interaction between spodumene and reagents, to develop new and efficient flotation reagents and to optimize the mineral processing process.