Abstract: This is an article in the field of mineral processing engineering. The study objects are a spodumene waste rock in Sichuan. According to the mineral characteristics of thisspodumene waste rock, heavy medium separation tests were carried out at three different feed particle sizes (-15+0.5 mm, -10+0.5 mm, -5+0.5 mm) of the spodumene waste rock in laboratory. The test results show that the application of heavy medium separation in beneficiation of spodumene waste rock is very effective, and when -10+0.5 mm is used as the feed particle size range of the subsequent waste rock in heavy medium separation, and 2.70 g/cm³ is selected as the separation density, the results of heavy medium separation effect is relatively good. However, according to the actual production of heavy medium separation test results, the separation index is relatively good when the selected particle size is -15+0.5 mm and the medium density is 2.0 g/cm³.