Abstract: This is an article in the field of metallurgical engineering. Titanium gypsum is an industrial waste residue mainly composed of calcium sulfate dehydrate when the titanium dioxide is produced by the sulfuric acid method. At present, the utilization rate of titanium gypsum is relatively low due to its high impurity content , difficulty in dehydration and poor mechanical properties of the subsequent products. A large amount of titanium gypsum stored in the open air has caused great environmental and economic stress on the titanium dioxide enterprises, which is a serious waste of land resources. In this article, the current situation and research progress of global titanium gypsum in building materials, chemical industry, agriculture and climate change were summarized. The suggestions and prospects for the effective reduction and high-quality resource utilization of titanium gypsum from the aspects of structure adjustment, technological innovation, green development, standard formulation and policy support were provided.