Abstract: This is an article in the field of mineral processing engineering. In this article, the recovery and utilization under the condition of origin potential of galena and sphalerite from a lead-zinc tailings containing cadmium in Guangxi was studied. Research indicates S19 exhibits satisfactory recovery for galena, while CZ008 as a novel collector for zinc flotation can effectively recover activated-sphalerite. Flotation tailings may serve as a silicate excipient for cement after gravity concentration in cleaning table and desulfurization. The wastewater produced by the process can be recycled without treatment and will not affect the recovery index.