Abstract: This is an article in the field of mineral processing engineering.Tailings in China are rich in strontium-barium-bearing minerals and fluorite minerals. Due to the complex distribution relationship of the minerals, it’s very difficult to recover the minerals. In this article, the mixed flotation and separation beneficiation process was developed for the utilization of the tailings. The research results indicate that for the tailings with 8% SrO grade and 16% CaF₂ grade, the fluorite concentrate with 91% CaF₂ grade and the strontium-barium bearing mineral concentrate with more than 90% mineral purity can be obtained. The research results can provide technical support for tailings resource utilization, reduction and harmlessness in China.