Abstract: This is an article in the field of mining processing engineering. The article takes fine-grained hematite concentrate as the research object, explores the effects of the molecular weight of flocculant, the concentration of flocculant, the dosage of flocculant, and slurry temperature on the flocculation and settlement effect of fine-grained hematite concentrate. At the same time, through dynamic analysis, the flocculation and settlement dynamic model that conforms to fine-grained hematite concentrate is explored. The results show that APAM with a molecular weight of 9 million, a preparation concentration of 0.05%, and a dosage of 60 g/t has a good settling effect and lower cost. The addition of APAM significantly improves the settling effect, while high APAM molecular weight results in fast settling speed and low final underflow concentration. Low APAM concentration results in fast settling speed and high final underflow concentration. Increasing the APAM dosage results in a faster settling speed and an increase in floc particle size, but both rates of increase gradually slow down, ultimately resulting in a decrease in underflow concentration. As the temperature of the slurry increases, the settling speed increases, but the growth rate is not very significant, and the concentration of underflow increases. The dynamic analysis of flocculation and settlement of fine-grained hematite concentrate by APAM shows that the hyperbolic dynamic model equation has achieved good fitting. APAM can prioritize using the hyperbolic dynamic model 1/(1- \dfraccc_0 )= \dfrackt+b to describe the flocculation and settlement dynamic of fine-grained hematite concentrate.