Abstract: This is an article in the field of mining engineering. The process mineralogy is the prerequisite for flotation. The influence of ore fineness and the degree of dissociation of the target mineral monomer on ore floatability can be used to guide the selection of suitable flotation conditions. A systematic study of the process mineralogy of a copper-cobalt ore was carried out using the methods of X-ray fluorescence analysis, X-ray powder diffraction analysis, scanning electron microscopy, and electron polarizing microscopy. Based on the process mineralogy studies, the flotation tests were carried out, at the condition of grinding fineness of -0.074 mm 70%, with a process of one roughing-two scavenging-two cleaning closed-circuit flowsheet. The sulfide concentrate with the grade of Cu 21.04%, Co 9.83% and the recovery of Cu 92.88%, Co 92.84% was achieved.