Abstract: In order to improve the utilization efficiency of acid leaching vanadium tailing, the sintered ceramsite for building was prepared by adding clay and fly ash with Shangluo Qianjiaping vanadium tailing as the main raw material. The proportion of materials, the parameters of granulation process, the preheating and roasting conditions in the preparation of ceramsite were systematically studied. The results show that when the ratio of vanadium tailing, clay and fly ash is 6:1:3, granulating water granulation water consumption is 18%, granulation time is 15 min, preheating temperature is 400℃, preheating time is 30 min, roasting temperature is 1160℃, roasting time is 20 min, the high strength ceramsite with compression strength of 11.58 Mpa, packing density of 1014.7 kg/m³ and water absorption of 5.61% can be obtained. SEM and XRD analysis indicate that in the process of ceramsite synthesis, quartz, anorthite and albite phases has been generated and formed mineral aggregates with compact structure and good pore skeleton, thus increasing the strength of ceramsite.