Abstract: Grades of Fe, TiO₂ and S in the vanadium titanium magnetite concentrate in Panxi are 53.75%, 12.55% and 0.76%. Fe and Ti are mainly in the form of vanadium-titanium magnetite and ilmenite, while sulfur is mainly in the form of magnetic pyrite. In order to reduce the sulfur content of this vanadium titanium magnetite concentrate, a study on desulfurization was carried out by flotation. Results show that adopting the flotation closed circuit process with once roughing, four times cleaning and twice scavenging, the sulfur concentrate with S grade of 28.65% and S recovery of 59.46%, and iron concentrate with TFe grade of 53.79%, TFe recovery of 98.51%, S grade of 0.29 % can be obtained with the following conditions: sulfuric acid as pH regulator, butyl xanthate + ammonium butyrate (5:1) as collector, 2^# oil as frother, of which the dosage were 2000 g/t, 300 g/t, 40 g/t in roughing and regrinding fineness of sulfide concentrate by roughing and scavenging was -38 μm content of 93.33 %.