Abstract: The gold ore type of the gold mining in Laos is altered rock. Gold is the only recyclable element in the ore. Metal minerals are mainly iron sulfides. Part of the gold is wrapped in sulfide, which belongs to the refractory gold ore. The environmentally friendly gold leaching test was carried out for this ore, and obtain the best process parameters as: under the condition of the ore gold grade of 5.47 g/t, the grinding fineness of -0.074 mm content 90%, slurry concentration 40%, lime dosage 3000 g/t, leaching aid dosage of potassium ferricyanide 600 g/t, pretreatment 2 h after dosing alkali and leaching aid, dosage of Jinchan leaching agent 3000 g/t, leaching time 32 h, the gold leaching rate can be over than 93.97%. At the same time, conditional verification tests show that, under the best process conditions, the gold leaching rate is relatively stable.