Abstract: Sulfuric acid was used as the leaching medium, and the leaching conditions, including acid concentration, liquid-solid ratio and temperature, were optimized by response surface methodology and Box-Behnken design (BBD). The results showed that the acid concentration was the most important factor, followed by temperature and liquid-solid ratio. Through response surface optimization, the optimal process conditions were determined as follows: acid concentration of 116.77 g/L, liquid-solid ratio of 8, and temperature of 170℃. Under these conditions, the arsenic extraction rate of copper converter reached 94.49%, indicating that the acid extraction experiment of lead converter arsenic ash could be successfully optimized by response surface methodology.