Abstract: MPT method is an alteration information extraction method based on the data processing process of "mask technology + principal component analysis + threshold classification". It can quantitatively extract the weak alteration information in principal components and classify them based on the effective exclusion of vegetation, ice, snow and water. In this paper, based on Landsat8 OLI data and MPT method, iron staining and hydroxyl alteration information in Dagelegou area were extracted and compared with the known geological background. The results showed that the comprehensive alteration anomaly information of iron staining and hydroxyl in the existing gold polymetallic ore detailed survey area were highly consistent with the distribution of Au, Cu and Mo anomalies in river sediments, copper and gold orebodies and fracture alteration zones, and the remote sensing alteration anomaly information could effectively indicate the mineralization location. Based on the comprehensive alteration anomaly information, anomaly verification analysis results and regional geological background, five metallogenic prospects were delineated, which provided reference for further prospecting work in this area.