Abstract: A copper-molybdenum ore in Qinghai contains 0.084% Mo and 0.067% Cu. Process mineralogical study shows that molybdenum in the ore mainly exists in the form of molybdenite, while copper in the form of chalcopyrite, chalcocite and bornite. Based on the molybdenum ore property, the flowsheet of selective flotation was adopted．Copper and molybdenum were comprehensively recovered by flotation process. Under the condition of grinding fineness of 74 μm 70%, molybdenum concentrate was obtained by one roughing, one scavenging and two blank cleaning. After regrinding, molybdenum concentrate with molybdenum grade of 50.21% and recovery of 85.21% was obtained by three cleaning. After molybdenum flotation tailings were activated with copper sulfate, copper concentrate with grade of 15.32% and recovery of 54.92% was obtained by one roughing, one scavenging and four cleaning. The comprehensive recovery of valuable elements was realized.