Abstract: This is an essay in the field of mineral processing engineering. Li₂O grade of a spodumene ore in Xinjiang is 1.04%. The lithium-containing minerals are mainly spodumene, Lithium-Muscovite and montebrasite. The gangue minerals are mainly quartz, albite and potassium feldspar. Under the condition of grinding finness -0.074 mm content 79.4%, using self-developed collector EM-PN51, the concentrate productswith Li₂O grade 5.36%, Nb₂O₅ content 0.071%, Ta₂O₅ content 0.044% and Li₂O recovery rate 87.38%, Nb₂O₅ recovery rate 87.33%, Ta₂O₅ recovery rate 88.26% can be obtained bythe closed flotation circuit of one-roughing, one-scavenging, three-cleaning. The comprehensive recovery of several valuable components in spodumene ore is realized.