Abstract: This is an essay in the field of mineral processing engineering. In this paper, a rare earth and associated fluorite resource in Henan Province was studied. Based on the results of process mineralogy and small beneficiation experiments, an extended continuous test with a capacity of 60 kg/h was carried out. Through chemical analysis and AMICS microscopic identification, it was found that the content of REO and CaF₂ was 1.53% and 18.22%, respectively. The target minerals for REO separation were hamartite and parisite. The process of "mixed flotation - separation flotation of REO and fluorite " was used to recover REO and fluorite from ores. On this basis, the extended continuous test was carried out, and finally obtained the rare earth concentrate with REO grade of 52.54% and recovery rate of 51.15%, and the fluorite concentrate with a CaF₂ grade of 94.76% and recovery rate of 60.80%. The concentrate product index was good, and comprehensive recovery and utilization of REE associated fluorite were preliminarily realized. It is helpful to provide technical support for the production of enterprises and provide a basis for the comprehensive development and utilization of the same type of rare earth and co-associated resource deposits.