Abstract: This is an essay in the field of mineral processing engineering. Barite is an important non-metallic mineral with the characteristics of large proportion, non-toxic, non-magnetic, easy to absorb rays, etc. It is mainly used for oil and gas drilling mud weighting agent, preparation of barium-containing chemical products and barium alloys. China is a major exporter of barite. This paper conducts beneficiation test research on low-grade barite ore from Guizhou, China. After the closed-circuit test of “one roughing, one scavenging and two cleaning”, sodium carbonate as regulator, water glass as inhibitor and sodium dodecyl sulfate as collector, a barite concentrate with a BaSO₄ grade of 90.38% and a recovery of 91.78% has been obtained. The test technical indicators are good, and the concentrate meets the requirements of the first grade chemical barite. The research results can provide important technical support and reference for the development and utilization of barite resources.