Abstract: This is an essay in the field of mineral processing. Copper ore in Xinjiang was refractory oxidized copper ore,of which the mineral composition was complex. In the ore copper sulfide accounts for 35.97% of the total copper, free copper oxide and combined copper oxide account for 64.03%. There were many gangue minerals, the intercalation of useful minerals and gangue minerals was complex. The technical conditions of mineral processing were studied by the principle flow of flotation copper sulfide minerals and then copper oxide minerals. According to the properties of the ore, a flotation condition test was carried out to obtain the best process parameters. And the optimum process parameters that grinding fineness -0.074 mm accounted for 65%, the amount of lime was 2500 g/t, the amount of collector Z-200 was 100 g/t, the amount of sodium sulfide was 1750 g/t, the amount of ammonium sulfate was 550 g/t, the amount of sodium amyl xanthate was 160 g/t were obtained. When the grinding fineness was -74 μm 65% and the best pharmaceutical system was adopted, two kinds of copper sulfide concentrate and copper oxide concentrate can be obtained by closed circuit process. The Mixed copper concentrate with copper grade of 25.59%,silver grade of 507.27 g/t,and copper recovery ratio of 73.07%, silver recovery ratio of 70.27% was obtained. The efficient utilization of copper oxide resources was provided by this study.