Abstract: This is an essay in the field of mineral processing engineering. Lead-zinc mine is one of the important strategic mineral resources in our country, and it is generally poor, fine and complex. Lead-zinc sulfide deposit is about 90% of total reserves. At present, flotation is the most commonly used method for the beneficiation of lead-zinc sulfide ore, and the selection of flotation reagents plays a decisive role in the flotation process index. In this paper, recent research progress of zinc sulfide flotation reagents is summarized, emphatically introduces the collecting agent, inhibitor and activator, analyzes the future the key research direction of zinc sulfide flotation, finally points out that the microbe as flotation reagents zinc sulfide flotation in the broad application prospect in the future, to achieve efficient vulcanization lead-zinc separation to provide technical and theoretical support.