Abstract: This is an essay in the field of mineral processing engineering. Cyanide tailings of a gold mine contain gold 0.45 g/t, and the gold mainly exists in the form of vulcanized gold and is mainly distributed in coarse particles. After the classification treatment, for the +0.037 mm ore sample, under the condition of grinding fineness -0.037 mm content of 15%, by using floatation flowsheet “one roughing-two scavenging-three cleaning”, the gold concentrate with the grade of 21.25 g/t, and the operation recovery 72.27%. The Result shows that the cyanide tailings can be comprehensively recovered.