Abstract: This is an article in the field of mining processing engineering. Quartz sand for photovoltaic glass is one of the essential raw materials to support the development of the new energy industry, and its supply security is related to the successful implementation of China's two-carbon policy. In this paper, one of the essential raw materials for development, its supply security is related to the successful implementation of China's two-carbon policy. In this paper, a large quartz sand mine in Enshi Prefecture of Hubei Province was studied, and process mineralogy and purification were carried out. It was found that the main impurities of this quartz sand mine were plagioclase, mica, limonite and rutile. The mineral processing of "fractionation-gravity separation-magnetic separation-acid leaching" was adopted, and the yields of quartz sand that met the particle size requirements (0.106 ～ 0.500 mm)were 67.61%, the content of SiO₂ was increased from 97.36% to 99.79%, and the contents of harmful elements Fe₂O₃, TiO₂ and Al₂O₃ were separately reduced to 75, 80 and 630 g/t. The quartz concentrates meet the production requirements of siliceous raw materials for photovoltaic glass, realizing the effective utilization of the quartz sand ore.