Abstract: This is an article in the field of mining environment. Most of the uranium mines discovered and mined in my country are located in Hunan, Jiangxi, and Guangdong. With the delineation of the ecological red line and the increasing attention of the people to ecological and environmental issues, environmental restoration of uranium mines becomes more and more important. This article briefly introduces the mining methods of uranium mines in southern China, systematically analyzes the impact of the production process of uranium mines on the environment, focuses on the principles and applications of physical, chemical, and biological remediation measures, summarizes the corresponding advantages and disadvantages, and prospects the future development of mine restoration. It was pointed out that the next step should be focused on environmental testing before the decommissioning of uranium mines and related facilities, and comprehensive environmental data collection and recording of the entire production process of the mine. Close attention should be paid to the treatment and disposal of wastewater from uranium mines, increase research investment, learn from foreign advanced technology and methods, and use comprehensive repair technology to repair the polluted environment more efficiently, safely and quickly. The restoration of uranium mines would be combined with rural governance, develop tourism, and increase the development motivation and income levels of local residents.