Abstract: This is an article in the field of mineral processing engineering. Copper is an important non-ferrous metal resource. With the increasing reduction of easily processed copper sulfide, the development and utilization of copper oxide is an important content of research in the mining field. Flotation is the main method to treat copper oxide. This paper summarizes the relevant research progress of copper oxide flotation in recent years, details the development status of direct flotation, sulfide flotation and other flotation methods, analyzes the flotation reagents, and discusses the future development direction of copper oxide flotation, aiming to provide an important theoretical basis for efficient separation of copper oxide.