Abstract: This is an article in the field of mineral processing engineering. For a skarn copper ore, the disseminated particle size is fine, the valuable elements in the ore are Cu, S, Fe and the associated element Ag. Compared with the effects of copper preferential flotation and copper-sulfur mixed flotation-copper-sulfur separation on the comprehensive recovery, the copper-sulfur mixed flotation-copper-sulfur separation process can achieve better recovery of copper, sulfur and silver, and magnetite has a certain recovery value. Copper concentrate with copper grade of 24.39% and copper recovery of 91.68% and sulfur concentrate with sulfur grade of 33.10% and sulfur recovery of 61.19% were obtained by copper sulfur mixed flotation. Ag was enriched in the copper concentrate, with a grade of 185 g/t and Ag recovery of 83.21%. The recovery of iron concentrate can be increased after the regrinding magnetic separation of flotation tailings. With two-stage weak magnetic separation, iron concentrate with iron grade of 56.48% and iron recovery of 33.84% can be obtained. The results can provide a reference for the similar copper sulfide.