Abstract: This is an article in the field of mineral processing engineering. The opper polymetallic ore in a high-altitude mining area in Xizang has a high oxidation rate and complex ore properties. In order to make full, efficient and comprehensive use of mineral resources, this article analyzes and studies the mineral properties and characteristics of the raw ore based on theory and practical experience. Finally, the flotation process with JM-1 sulfide agent, ZJ-1 collector, copper, lead and zinc mixed flotation of "sulfur before oxygen" as the key technology is determined. At the condition that the copper oxidation rate of the raw ore is 38.58%, the mixed concentrate grade sum of lead and zinc is 41.17%, and the recovery of copper, lead and zinc is 58.74%, 80.71% and 70.82%, respectively, after two roughing, three cleaning and two scavenging processes, which greatly improves the utilization effect and technical level of dressing. It also provides technical support and favorable basis for the improvement and innovation of mineral processing technology in the later stage.