Abstract: This is an article in the field of mineral processing engineering. The gold mineral in an arsenic bearing high sulfur gold mine has a close symbiotic relationship with pyrite and arsenopyrite, and the recovery rate of concentrate gold is not ideal in the actual production process. In order to improve the recovery rate of concentrate gold and take into account the grade of concentrate gold, according to the characteristics of this mineral, the flotation process parameters and process are obtained through system condition test, flotation time test and beneficiation test, and then the open circuit test and closed circuit test are carried out to obtain better flotation indexes. In order to further improve the flotation index, the regrinding and flotation test of flotation middling is carried out, and the cyanide leaching test of middling regrinding flotation tailings is carried out. Finally, the satisfactory index of 91.94% of the total recovery of gold dressing and metallurgy is obtained.