Abstract: Chalcopyrite is often associated with some impurity minerals such as pyrite, quartz, carbonateand silicate minerals, and the presence of these minerals will affect the leaching of chalcopyrite.Additionally, to promote the dissolution of chalcopyrite,some oxidants often need to be added in its leaching process, which generates manyunavoidable ions.Therefore, involving the ions produced from the dissolution of impurity minerals will affect the leaching efficiency of chalcopyrite.In this paper, the effect of the typical impurity minerals and ions on chalcopyrite dissolution was reviewed for providinga theoretical foundation for the high-efficiency and complete CuFeS₂leaching.