Abstract: When the technology of high pressure pre-oxidation-cyanide leaching of gold was adopted for the high sul-fur high arsenic gold concentrate containing the organic carbon, the leaching rate of gold was improved from 10% toabout 97%. In order to optimize the process parameters,effects on pre-oxidation and cyanide were studied. At thesame time, comprehensive treatment for the arsenic-containing acid waste water from pre-oxidation was studied.